Why is GoutClear™ So Effective?

Doctor Formulation

GoutClear™ is a breakthrough proprietary treatment that effectively combines the most powerful and extensively researched ingredients, giving you an all-in-one solution. Every single ingredient in GoutClear™ was hand-picked by a team of medical doctors and scientific researchers, based on clinical data and designed to help relieve and prevent gout suffering, achieving results more effectively than any other gout treatment available.

GoutClear™ contains 9 tested ingredients that meet the strength and purity standards of the USP/NF (United States Pharmacopeia–National Formulary). Each ingredient was carefully researched and included based on clinical data. No other non-prescription solution comes close to in terms of quality and purity of ingredients. GoutClear™ also offer an additional Tart Cherry Extract supplement to boost the benefits that this clinically proven ingredient can bring.

Recommended use for adults is to take 2 (two) capsules daily with meals. Capsules can be taken together in the morning with breakfast, or for optimal support take 1 (one) in the morning and 1 (one) in the evening as a dietary supplement.

GoutClear™ 's - Proprietary Blend of Ingredients:

Click here to see our label.

Tart Cherry (Prunus cerasus) Improves the body's ability to reduce inflammation and deal with oxidative stress such as it might occur with exercise or when joints are inflamed. It contains significantly high levels of anthocyanins, which work to reduce uric acid production and build up. Tart Cherry also provides strong antioxidant and anti-inflammatory properties due to the high levels of anthocyanins and supporting compounds, much more than its sweeter counterpart. This is possibly due to the fact the anthocyanidins inhibit xanthine oxidase, an enzyme involved in the production of uric acid, therefore lowering uric acid production. Studies have shown that cherry juice can reduce gout attacks by up to 45%.

*References:
  • Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial. Kuehl KS, Perrier ET, Elliot DL, Chesnutt JC. J Int Soc Sports Nutr. 2010 May 7;7:17.
  • Tall JM, Seeram NP, Zhao C, Nair MG, Meyer RA, Raja SN. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behav Brain Res. 2004 Aug 12;153(1):181-8
  • Zhang Y, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi HK. Cherry consumption and decreased risk of recurrent gout attacks. Arthritis Rheum. 2012 Dec;64(12):4004-11.
  • Martin KR, Bopp J, Burrell L, Hook G. The effect of 100% tart cherry juice on serum uric acid levels, biomarkers of inflammation and cardiovascular disease risk factors. FASEB J. April 2011;25 (Meeting Abstract Supplement):339.2.
  • Tart cherry juice decreases oxidative stress in healthy older men and women. Traustadóttir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM. J Nutr. 2009 Oct;139(10):1896-900.
  • Tart cherry juice decreases oxidative stress in healthy older men and women. Traustadóttir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM. J Nutr. 2009 Oct;139(10):1896-900.

Folic Acid (Vitamin B9) is a water soluble B vitamin - folate being the natural source we derive from food, and folic acid being the synthetic derivative of this vitamin. It is essential for a range of bodily functions including the production of DNA. In terms of benefits for gout sufferers, it has been suggested that this vitamin neutralizes the enzyme, called xanthine oxidase, responsible for uric acid production.

*References:
  • Kamen B (October 1997). "Folate and antifolate pharmacology". Semin. Oncol. 24 (5 Suppl 18): S18–30–S18–39.
  • Dietary supplement fact sheet: Folate". Health Information. Office of Dietary Supplements, US National Institutes of Health.

Artichoke (Cynara cardunculus var. scolymus) contain a vast array of vitamins (mainly B complex) and minerals (iron, magnesium and potassium) that provide a range of antioxidant, antimicrobial and anti-inflammatory elements. The flower of the artichoke has been used as a food and medicinal agent for centuries. Artichoke provides diuretic qualities that are thought to flush out toxins, namely unwanted uric acid, that if left behind, can crystallize and cause gout. Furthermore, studies suggest that artichokes may inhibit the enzyme (XO) responsible for uric acid production.

*References:
  • Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application. Sarawek S, Feistel B, Pischel I, Butterweck V. Planta Med. 2008 Feb;74(3):221-7.
  • Libby: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed. 2007 Saunders. Chapter 47.
  • Gout and Uric Acid Education Society: About Gout. http://gouteducation.org/patient/what-is-gout/
  • National Institute of Arthritis and Musculoskeletal Diseases: NIH: Gout. http://www.niams.nih.gov/Health_Info/Gout/gout_ff.asp.

Garlic (Allium sativum) is well recognized for it's anti-fungal, anti-bacterial, antiseptic and anti-parasitic properties. There is some evidence to suggest that garlic and it's active compounds may increase glutathiones level and glutathione related enzymes, which aid in detoxifying the body, ridding it of unwanted uric acid. Evidence suggests a mild improvement in gout symptoms. The main beneficial effects are for heart health and lowering cholesterol. There is a mild lowering of LDL cholesterol (often referred to as "bad cholesterol") and triglycerides.

*References:
  • Ferri: Ferri's Clinical Advisor 2011, 1st ed. Appendix Ib.
  • "Garlic: A natural antibiotic". ACM Modern Drug Discovery April 2002 Vol. 5, No. 4, p 12. April 1, 2002.
  • Kodera Y., Matuura H., Yoshida S., Sumida T., Itakura Y., Fuwa T., Nishino H. (January 30, 1989). "Allixin, a stress compound from garlic"
  • "Health effects of garlic. American Family Physician by Ellen Tattelman, July 1, 2005". Aafp.org.

Yucca Herb Stock Leaf is is an anti-inflammatory agent which also contains antioxidant properties that has been traditionally used for rheumatic diseases such as arthritis for many years. The yucca plant also contains resveratrol, a potent antioxidant and a recent review of the literature indicated that yucca holds promise in the treatment of arthritis and other inflammatory conditions such as gout.

*References:
  • Wenzig EM, Oleszek W, Stochmal A, Kunert O, Bauer R. Influence of phenolic constituents from Yucca schidigera bark on arachidonate metabolism in vitro. J Agric Food Chem. 2008 Oct 8;56(19):8885-90.b
  • Piacente S, Montoro P, Oleszek W, Pizza C., Yucca schidigera bark: phenolic constituents and antioxidant activity. J Nat Prod. 2004 May;67(5):882-5.
  • Olas B, Wachowicz B, Stochmal A, Oleszek W. Inhibition of oxidative stress in blood platelets by different phenolics from Yucca schidigera Roezl. bark., Nutrition. 2003 Jul-Aug;19(7-8):633-40.
  • Cheeke PR, Piacente S, Oleszek W., Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review. J Inflamm (Lond). 2006 Mar 29;3:6.

Milk Thistle (Silybum marianum) Healthy liver functioning is important for the treatment and prevention of gout. Silymarin or Silybum marianum from the herb, milk thistle, supports the wellbeing of the liver. Many standard treatments for gout involve medications that can be toxic to the liver. Used in traditional Chinese medicine to soothe the liver, promote bile flow and relieve toxic material it may contain hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.

*References:
  • Rakel: Integrative Medicine, 2nd ed. 2007 Saunders. Chapter 84.
  • Rainone, Francine (2005). "Milk Thistle". American Family Physician 72 (7): 1285–8. PMID 16225032.
  • Wang L, Waltenberger B, Pferschy-Wenzig EM et al. (July 2014). "Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review". Biochemical Pharmacology 92: 73–89.
  • Jayaraj R, Deb U, Bhaskar AS, Prasad GB, Rao PV (2007). "Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice". Environmental Toxicology 22 (5): 472–9.

Turmeric Root (Curcuma longa) often called the "Spice for Life" holds many potent therapeutic properties and has been used medicinally for centuries. It contains curcumin, which is reported to have anti-inflammatory, antioxidant and anti-arthritic properties. It is believed to inhibit the synthesis of prostaglandins in the body that are involved with pain and thought to stimulate the adrenal glands to release cortisone within the body. Turmeric is an effective natural ingredient that can provide relief from pain and reduce inflammation..

*References:
  • Rakel: Integrative Medicine, 2nd ed. 2007 Saunders. Chapter 48.
  • Jurenka JS. Altern Med Rev. 2009 Jun; 14(2):141-53.
  • Bharat B. Aggarwal and Kuzhuvelil B. Harikumar. Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases. Int J Biochem Cell Biol. 2009; 41(1): 40–59.
  • Shehzad A, Rehman G, Lee YS. Biofactors. 2013 Jan-Feb; 39(1):69-77. Epub 2012 Dec 22.
  • Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Adv Exp Med Biol. 2007; 595:1-75.

Dandelion Extract (Taraxacum) contains a number of different active constituents, including quercetin, luteolin and inulin which help maintain a healthy liver. In gout, dandelion extract is most useful for its anti-inflammatory and antioxidant properties, as well as for its abilities to stimulate the urinary excretion of uric acid, thought to be the cause of gout pain.

*References:
  • Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7.
  • Mascolo N, Autore G, Capassa G, et al. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res 1987:28-9.
  • Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7.
  • Grases, F., Melero, G., Costa-Bauza, A., Prieto, R., and March, J. G. Urolithiasis and phytotherapy. Int Urol Nephrol. 1994;26(5):507-511
  • Hu, C. and Kitts, D. D. Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Mol.Cell Biochem 2004;265(1-2):107-113.
  • Katrin Schütz, Reinhold Carle & Andreas Schieber (2006). "Taraxacum—a review on its phytochemical and pharmacological profile". Journal of Ethnopharmacology 107 (3): 313–323.

Rutin contains anti-inflammatory and antispasmodic qualities to assist in balancing hormonal equilibrium. In addition to decreasing the inflammatory response of the cerebral neurovascular system it can reduce vasospasms often experienced during a gout attack. Rutin leaf extract has some effect on inhibiting the enzyme responsible for making gout crystals (i.e. XO or xanthine oxidase that generates uric acid), and preventing the formation of uric acid crystals within the joint that causes gout.

*References:
  • Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. Ahmad NS, Farman M, Najmi MH, Mian KB, Hasan A. J Ethnopharmacol. 2008 May 22;117(3):478-82.
  • Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. Zhu JX, Wang Y, Kong LD, Yang C, Zhang X. J Ethnopharmacol. 2004 Jul;93(1):133-40.
  • Purification and identification of active antibacterial components in Carpobrotusedulis L. Elmarie van der Watt and Johan C Pretorius, Journal of Ethnopharmacology, Volume 76, Issue 1, June 2001, Pages 87–91.
  • Antioxidant and Antibacterial Properties of Mesembryanthemum crystallinum and Carpobrotus edulis Extracts. Bouftira Ibtissem, Chedly Abdelly and Souad Sfar, Advances in Chemical Engineering and Science, 2012, Vol. 2 No. 3, pages 359-365.
  • Guardia; Juarez, AO; Pelzer, LE et al. (2001). "Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat". Il Farmaco 56 (9): 683–7.


GoutClear™ Tart Cherry:

Click here to see GoutClear™ Tart Cherry label.

Tart Cherry contains substantial antioxidant and anti-inflammatory properties due to the high levels of anthocyanins and supporting compounds, more than its sweeter counterpart. For many years, gout sufferers have relied on cherry juice to reduce symptoms and attacks of this often debilitating condition. As the build-up and abnormal levels of uric acid in joints and soft tissues are thought to be responsible for gout, tart cherry properties work to help reduce uric acid levels. This is possibly because the anthocyanidins it contains inhibit xanthine oxidase, an enzyme involved in the production of uric acid, therefore lowering uric acid production. One study suggests that cherry juice can reduce gout attacks by up to 45%. An added boost of powerful antioxidant anthocyanins may help lower inflammatory COX 1 & COX 2, promote normal uric acids levels and alleviate pain associated with gout.
*References:
  • Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial. Kuehl KS, Perrier ET, Elliot DL, Chesnutt JC. J Int Soc Sports Nutr. 2010 May 7;7:17. http://lpi.oregonstate.edu/infocenter/vitamins/bio...
  • Tart cherry juice decreases oxidative stress in healthy older men and women. Traustadóttir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM. J Nutr. 2009 Oct;139(10):1896-900.
  • Martin KR, Bopp J, Burrell L, Hook G. The effect of 100% tart cherry juice on serum uric acid levels, biomarkers of inflammation and cardiovascular disease risk factors. FASEB J. April 2011;25 (Meeting Abstract Supplement):339.2.
  • Zhang Y, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi HK. Cherry consumption and decreased risk of recurrent gout attacks. Arthritis Rheum. 2012 Dec;64(12):4004-11.
  • Tall JM, Seeram NP, Zhao C, Nair MG, Meyer RA, Raja SN. Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. Behav Brain Res. 2004 Aug 12;153(1):181-8.